Knowledge representation by connection matrices: A method for the on-board implementation of large expert systems

Extremely large knowledge sources and efficient knowledge access characterizing future real-life artificial intelligence applications represent crucial requirements for on-board artificial intelligence systems due to obvious computer time and storage constraints on spacecraft. A type of knowledge representation and corresponding reasoning mechanism is proposed which is particularly suited for the efficient processing of such large knowledge bases in expert systems

Transition to finger convection in double-diffusive convection

Finger convection is observed experimentally in an electrodeposition cell in which a destabilizing gradient of copper ions is maintained against a stabilizing temperature gradient. This double-diffusive system shows finger convection even if the total density stratification is unstable. Finger convection is replaced by an ordinary convection roll if convection is fast enough to prevent sufficient heat diffusion between neighboring fingers, or if the thermal buoyancy force is less than 1/30 of the compositional buoyancy force. At the transition, the ion transport is larger than without an opposing temperature gradient

Creature forcing and large continuum: The joy of halving

For $f,g\in\omega^\omega$ let $c^\forall_{f,g}$ be the minimal number of uniform $g$-splitting trees needed to cover the uniform $f$-splitting tree, i.e., for every branch $\nu$ of the $f$-tree, one of the $g$-trees contains $\nu$. Let $c^\exists_{f,g}$ be the dual notion: For every branch $\nu$, one of the $g$-trees guesses $\nu(m)$ infinitely often. We show that it is consistent that $c^\exists_{f_\epsilon,g_\epsilon}=c^\forall_{f_\epsilon,g_\epsilon}=\kappa_\epsilon$ for continuum many pairwise different cardinals $\kappa_\epsilon$ and suitable pairs $(f_\epsilon,g_\epsilon)$. For the proof we introduce a new mixed-limit creature forcing construction

Living in pandemic times

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U.S. Radio in the 21st Century: Staying the Course in Unknown Territory

This essay examines the development of the radio industry in the United States as it makes its way into the 21st century. Issues of regulation, technology, commerce, and culture are addressed

Five minutes with Peter Kellner: “History could repeat itself in a British referendum on EU membership”

If there were to be a referendum held on the UK’s membership of the European Union, how would British citizens vote? EUROPP’s Managing Editor Stuart Brown spoke to Peter Kellner, President of YouGov, about current polling trends, the lessons from previous UK referendums, and the factors, such as David Cameron’s plan to renegotiate the UK’s membership, which might have a significant impact on the result

IL-13R alpha 2 reverses the effects of IL-13 and IL-4 on bronchial reactivity and acetylcholine-induced Ca2+ signaling

Background: The interleukins IL-4 and IL-13 play a key role in the pathophysiology of asthma. The interleukin receptor IL-13R alpha 2 is believed to act as a decoy receptor, but until now, the functional significance of IL-13R alpha 2 remains vague. Methods: Bronchial reactivity was quantified in murine lung slices by digital video microscopy and acetylcholine (ACH)-induced Ca2+ signaling was measured in human airway smooth muscle cells (ASMC) using fluorescence microscopy. Results: IL-4 or IL-13 up to 50 ng/ml induced bronchial hyperreactivity. But after incubation with 100 ng/ml this effect was lost and bronchial responsiveness was again comparable to the control level. The effects of IL-4 and IL-13 on bronchial reactivity were paralleled by the effects on ASMC proliferation. Fifty nanograms per milliliter of IL-4 and IL-13 increased the Ca2+ response of human ASMC to ACH. At 100 ng/ml, however, the effects of the cytokines on the Ca2+ response were no longer evident. The expression of IL-13R alpha 2 increased with increasing concentrations of IL-4 or IL-13, reaching its maximum at 100 ng/ml. Blocking IL-13R alpha 2, the loss of the effect of IL-4 and IL-13 at 100 ng/ml on human ASMC proliferation and the ACH-induced Ca2+ response were no longer present. Conclusions: IL-4 and IL-13 induce bronchial hyperreactivity by changing the Ca2+ homeostasis of ASMC. These effects are counteracted by IL-13R alpha 2. The biological significance of IL-13R alpha 2 might be a protective function by regulating IL-13- and IL-4-mediated signal transduction and thereby limiting pathological alterations in Th2-mediated inflammatory diseases. Copyright (c) 2007 S. Karger AG, Basel

“If They Could See Me Now!”: College Students Reflect on Their Experiences as Special Education Students in the K-12 System*

The current study examined the experiences of six students with learning disabilities in a four-year public, liberal arts college and discusses the meaning they attributed to their previous identification as special education students while in the K-12 system. Data was gathered through a semi-structured interview, questionnaire, and a sentence stem structure. A qualitative approach was used and results were analyzed using principles of content analysis. Themes emerging as noteworthy were: (a) the effect on relationships with peers, (b) lack of developmental knowledge by school support staff, (c) family support, and (d) the challenges of upholding expectations